Synthesis, spectral LFER and antimicrobial activities of some (E)-N׳-(1-(substituted phenyl)ethylidene)benzohydrazides

Venkatesan Manikandan, Selvaraj Balaji, Rajamohan Senbagam, Renganathan Vijayakumar, Murugan Rajarajan, Ganesan Vanangamudi, Rajasekaran Sundararajan, Renganathan Arulkumaran, Ganesamoorthy Thirunarayanan

Abstract


About eleven substituted (E)-N׳-(1-(substituted phenyl) ethylidene) benzo- hydrazides have been synthesized. They are characterized by their analytical, ultraviolet, infrared and NMR spectral data. The antibacterial and fungal activities of these chalcones have been evaluated.


Full Text:

PDF

References


W. O. Foye, Principles of Medicinal Chemistry, Varghese Publishing House, Bombay, III, Ed., 629, (1989).

I. S. Berdinskii, Chem. Heterocyclic Comp., 15(2), 238, (1979).

V. Polshettiwar, R. S. Varma, Tetrahedron Lett., 48(32), 5649, (2007).

S. Rollas, S. G. Kucukguzel, Molecules., 12, 1910, (2007).

L. Savini, L. Chiasserini, V. Travagli, C. Pellerano, E. Novellino, S. Cosentino, M. B.Pisano, Eur. J. Med. Chem., 39, 113, (2004).

V.L. Gein, L.F. Gein, M.V. Chirkova, V.A. Mikhalev, E.V. Voronina, Pharma. Chem. J., 39(8), 413, (2005).

H. Bayrak, A. Demirbas, N. Demirbas, S. A. Karaoglu, Eur. J. Med. Chem., 44, 4362, (2009).

B. Narasimhan, P. Kumar, D. Sharma, ActaPharmaceuticaSciencia, 52, 169, (2010).

P. Melnyk, V. Leroux, C. Sergheraert, P. Grellier, Bioorg. Med. Chem. Lett., 16, 31, (2006).

A. Nayyar, V. Monga, A. Malde, E. Coutinho, R. Jain, Bioorg. Med. Chem., 15, 626, (2007).

A. Imramovsky, S. Polanac, J. Vinsova, M. Kocevar, J. Jampitek, Z. Reckova, J. A. Kaustova, Bioorg. Med. Chem., 15, 2551, (2007).

Y. Janin, Bioorg. Med. Chem., 15, 2479, (2007).

J.P. Raval, N.H. Patel, H.V. Patel, P.S. Patel, Med. Chem. Res, DOI: 10.1007/s00044- 010-9324-3, (2010).

A. Bijev, Lett. Drug. Des. Discov., 3, 506, (2006).

U. Salgin-Goksen, N. Gokhan-Kelekci, O. Goktas, Y. Koysal, E. Kılıc, S. Isik.

G. Aktay, M. L. Ozalp, Bioorg. Med. Chem., 15, 5738, (2007).

R. Kalsi, M. Shrimali, T. N. Bhalla, J. P. Barthwal, Ind. J. Pharm. Sci., 52, 129, (1990).

Y. Xia, C.D. Fan, B.X. Zhao, J. Zhao, D.S. Shin, J.Y. Miao, Eur. J. Med. Chem., 43, 2347, (2008).

L. Troeberg, X. Chen, T.M. Flaherty, R.E. Morty, M. Cheng, H. Hua, C. Springer, J.H. McKerrow, G.L. Kenyon, J.D. Lonsdale-Eccles, T.H.T. Coetzer, F.E. Cohen, Mol. Med., 6, 660, (2000).

M. V. Lembege, S. Moreau, S. Larrouture, D. Montaudon, J. Robert, A. Nuhrich, Eur. J. Med. Chem., 43, 1336, (2008).

W. Porcal, P. Hernandeez, L. Boiani, M. Boiani, A. Ferreira, A. Chidichimo, J. J. Cazzulo, C.O. Azar, M. Gonzalez, H. Cerecetto, Bioorg. Med. Chem., 16, 6995, (2008).

J. Easmon, G. Purstinger, K.S. Thies, G. Heinisch, J. Hoffman, J. Med. Chem., 49, 6343, (2006).

P. C. Lima, L. M. Lima, K. C. M. da Silva, P. H. O. Leda, A. L. P. de Miranda, C. A. M. Fraga, E. J. Barreiro, Eur. J. Med. Chem., 35, 187, (2000).

S. G. Kucukguzel, A. Mazi, F. Sahin, S. Ozturk, J. Stables, Eur. J. Med. Chem., 38, 1005, (2003).

S. P. Sakthinathan, R. Suresh, V. Mala, K. Sathiyamoorthi, D. Kamalakkannan, K. Ranganathan, S. John Joseph, G. Vanangamudi, G. Thirunarayanan., Int. J. Sci. Res. Know., 1(11), 472, (2013).

S. P. Sakthinathan, R. Suresh, V. Mala, K. Sathiyamoorthi, D. Kamalakkannan, K. Ranganathan, R. Arulkumaran, S. Vijayakumar, R. Sundararajan, G. Vanangamudi, G. Thirunarayanan., Inter. Lett. Chem. Phy. Astro., 6, 77, (2013).

R. Suresh, D. Kamalakkannan, K. Ranganathan, R. Arulkumaran, R. Sundararajan, S. P. Sakthinathan, S. Vijayakumar, K. Sathiyamoorthi, V. Mala, G. Vanangamudi, K. Thirumurthy, P. Mayavel, G. Thirunarayanan, Spectrochim. Acta, 101A, 239, (2013).

R. Arulkumaran, S. Vijayakumar, S. P. Sakthinathan, D. Kamalakkannan, K. Ranganathan, R. Suresh, R. Sundararajan, G. Vanangamudi, G. Thirunarayanan, J. Chil. Chem. Soc., 2, 58, (2013).G. Thirunarayanan, M. Gopalakrishnan, G. Vanangamudi, Spectrochemica Acta., 67A, 106, (2007).

S. P. Sakthinathan, G. Vanangamudi and G. Thirunarayanan, Spectrochim. Acta, 95A, 693, (2012).

S. Sasikala, K. Thirumurthy, P. Mayavel and G. Thirunarayanan, Org. Med. Chem. Lett.: 2012. doi:10.1186/2191-2858-2-20.

G. Thirunarayanan, P. Mayavel, K. Thirumurthy, S. Dineshkumar, R. Sasikala, P. Nisha and A. Nithyaranjani, European Chem. Bull., 2(9), 598, (2013).

G. Thirunarayanan and K. G. Sekar, J. Taibah Univ. Sci. 8, 124, (2014).

M. Rajarajan, R. Vijayakumar, R. Senbagam, S. Balaji, V. Manikandan, G. Vanangamudi and G. Thirunarayanan, Int. Lett. Chem. Phys. Astro. 59, 147, (2015).

R. Vijayakumar, M. Rajarajan, R. Senbagam, S. Balaji, V. Manikandan, G. Vanangamudi and G. Thirunarayanan, Int. Lett. Chem. Phys. Astro. 59, 199 (2015).

A. W. Bauer, W. M. M. Kirby, J. C. Sherris, M. Truck, Am. J. Clin. Patho., 45, 493, (1966).

C. G. Swain, E. C. Lupton, J. Am. Chem. Soc., 90, 4328, (1968).




DOI: http://dx.doi.org/10.17951/aa.2016.71.2.29
Date of publication: 2017-04-03 12:28:05
Date of submission: 2015-11-05 13:02:45


Statistics


Total abstract view - 655
Downloads (from 2020-06-17) - PDF - 504

Indicators



Refbacks

  • There are currently no refbacks.


Copyright (c) 2017 Ganesamoorthy Thirunarayanan