Synthesis, spectral correlation analysis and evaluation of biological activities of some substituted hydrazones

Renganathan Vijayakumar, Rajamohan Senbagam, Murugan Rajarajan, Selvaraj Balaji, Venkatesan Manikandan, Ganesan Vanangamudi, Ganesamoorthy Thirunarayanan

Abstract


Some novel substituted hydrazone derivatives of amino guanidine have been synthesized with different substituted benzaldehydes by condensation method. The synthesized hydrazones were characterized by their physical constants, UV, IR and NMR spectra. The spectral data have been correlated with Hammett substituent constants and Swain–Lupton parameters. From the result of statistical analysis, the effects of substituents on the spectral data have been predicted. The antimicrobial activities of these synthesized hydrazone compounds have been screened by Bauer-Kirby method using human pathogenic bacteria and fungal species. The antimicrobial activities of all synthesized hydrazone compounds have shown significant activity.

Keywords


Hydrazones; UV; IR & NMR spectra; Correlation analysis; Antimicrobial activities

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References


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DOI: http://dx.doi.org/10.17951/aa.2015.70.2.103
Date of publication: 2016-02-15 12:20:04
Date of submission: 2016-02-15 11:18:00


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Copyright (c) 2016 Renganathan Vijayakumar, Rajamohan Senbagam, Murugan Rajarajan, Selvaraj Balaji, Venkatesan Manikandan, Ganesan Vanangamudi, Ganesamoorthy Thirunarayanan